The dialectic of private desire and public imperative — their conflict and interpenetration and mutual causation — has been the theme of the Troy story through three millennia. When W. B. Yeats wrote a poem about the irruption of sexual passion in the pattern of human events, and its incalculable aftermath in history, he restated powerfully for the twentieth century a perception which nevertheless goes back to Homer.

Cancer cells seem to exploit mechanisms that evolve as part of physiological tolerance, which is a complementary and often beneficial form of defense. The study of physiological systems of tolerance can therefore provide insights into the development of a state of host tolerance of cancer, and how to break it. Analysis of these models has the potential to improve our understanding of existing immunological therapeutic targets, and help to identify future targets and rational therapeutic combinations. The treatment of cancer with (...) immune checkpoint inhibitors aims to reverse the progression to tolerance of cancer, and achieve an immunogenic, rather than tolerogenic, homeostasis. Broadening the efficacy and durability of checkpoint inhibitors focuses on reversing tolerance and stimulating immunogenicity in the cancer, host, and environment. Two examples of important physiological states of tolerance that may inform tolerance of cancer are microbial infection and placental reproduction. These states of tolerance result from bilateral shaping of host and non‐self, akin to immunoediting in cancer, and offer reliable models to study the immune tolerance paradigm. (shrink)

This is a review of Christopher Gauker, CONDITIONALS IN CONTEXT (Cambridge, MA: The MIT Press, 2005).

Functional diversity holds the promise of understanding ecosystems in ways unattainable by taxonomic diversity studies. Underlying this promise is the intuition that investigating the diversity of what organisms actually do—i.e. their functional traits—within ecosystems will generate more reliable insights into the ways these ecosystems behave, compared to considering only species diversity. But this promise also rests on several conceptual and methodological—i.e. epistemic—assumptions that cut across various theories and domains of ecology. These assumptions should be clearly addressed, notably for the sake (...) of an effective comparison and integration across domains, and for assessing whether or not to use functional diversity approaches for developing ecological management strategies. The objective of this contribution is to identify and critically analyze the most salient of these assumptions. To this aim, we provide an “epistemic roadmap” that pinpoints these assumptions along a set of historical, conceptual, empirical, theoretical, and normative dimensions. (shrink)

Experiments are described, using electroencephalography (EEG) and simple tests of performance, which support the hypothesis that collapse of a quantum field is of importance to the functioning of the brain. The theoretical basis of our experiments is derived from Penrose (1989) who suggested that conscious decision-making is a manifestation of the outcome of quantum computation in the brain involving collapse of some relevant wave function. He also proposed that collapse of any wave function depends on a gravitational criterion. As different (...) brain areas are known to subserve different functions, we argue that `Penrose collapse' must occur in a particular brain area when performing a task that uses it. Further, taking an EEG from the area should amplify the gravitational prerequisite for collapse, so affecting task performance. There are no non-quantum theories which could lead one to expect that taking an EEG could directly affect task performance by subjects. The results of both pilot and main experiments indicated that task performance was indeed influenced by taking an EEG from relevant brain areas. Control experiments suggested that the influence was quantum mechanical in origin, and was not due to any experimental artefact. The results are statistically significant and merit attempts at replication in an independent laboratory, preferably with more sophisticated equipment than was available to us. (shrink)

This out of print work offered researchers a comprehensive and easy to use bibliography of primary and secondary works by or about Collingwood. More than 1,200 citations were listed alphabetically by standard bibliographical categories in this volume, which contained a periodical index as well as author and subject indexes. In addition, each book entry included a "review alert" listing the names of reviewers. Author notes clarified the significance of a listed work when this was not apparent from the title, and (...) the number of pages was indicated for very long or very short monographs. This volume remains a standard reference work for Collingwood scholars and it is available in research libraries around the country. (shrink)

We provide an overview of a proposal for a new metaphysical framework within which theology and science might both find a home. Our proposal draws on the triadic semiotics and threefold system of metaphysical categories of C. S. Peirce. We summarize the key features of a semiotic model of the Trinity, based on observed parallels between Peirce's categories of Firstness, Secondness, and Thirdness and Christian thinking about, respectively, the Father, Son, and Holy Spirit. We test and extend the semiotic model (...) by exploring how Peirce's taxonomy of signs offers a new approach to theological reflection on the Incarnation. This leads to a novel way of framing scientific questions about human evolution in semiotic terms and to a new approach to theological anthropology. Finally, we use the semiotic model of the Trinity as the basis of a trinitarian approach to the theology of creation according to which the semiotic processes that are fundamental to life and to human behavior and cognition may be understood as “vestiges of the Trinity in creation.”. (shrink)

We introduce a two-part collection of articles (Part 2 to appear in the September 2010 issue) exploring a possible new research program in the field of science and religion. At the center of the program lies an attempt to develop a new theology of nature drawing on the philosophy of C. S. Peirce. Our overall idea is that the fundamental structure of the world is exactly that required for the emergence of meaning and truth-bearing representation. We understand the emergence of (...) a capacity to interpret an environment to be important to the emergence of life, and we see the subsequent history of biological evolution as a story of increasing capacities for meaning making and meaning seeking. Theologically, we understand God to be the ground of all such meaning making and the ultimate goal of the universe's emerging capacity for interpreting signs. Here we explain our reasons for seeking a new metaphysical framework in which science and theology may each find a home. We survey the contributions to the two-part collection, and we suggest that the interdisciplinary collaboration from which these have arisen may serve as a methodological model for the field of science and religion. (shrink)

After acknowledging Wim Drees’s excellent contribution to the science-religion debate, this essay considers three ‘beyonds’ unhelpful to a response to the climate emergency. These are ‘beyond as sudden destruction’, stemming from an over-reliance on the apocalyptic texts of the New Testament; ‘beyond as up’, focussing on the release of the immortal soul from the material world; and ‘beyond time’, addressing the cosmological predictions of the ultimate end of the universe through God’s transformation of creation. The essay proposes in contrast that (...) the same event in the present can be viewed through four parallel lenses, of which eschatology is one. It draws on proposals from Drees’s Beyond the Big Bang and the detemporalised eschatology of Kathryn Tanner to propose an eschatology of the present moment, informed by divine judgment and longing, and the human vocation to respond to that judgment and longing with parallel longing, and with both action and consolation. (shrink)

In the preceding article in this section, F. LeRon Shults responds to our article preceding his, “Semiotics as a Metaphysical Framework for Christian Theology.” We respond here to his criticisms of our proposal. We discuss his concerns about the concept of “vestiges of the Trinity in creation” and argue that this does not undermine the absolute ontological difference between God and creation. We offer a clarification of our idea that the Incarnation may be understood, in terms of Peirce's taxonomy of (...) signs, as a qualisign of God's being. Finally, we discuss the idea that all symbols “break on the infinite.”. (shrink)

We introduce the second part of a two-part collection of articles exploring a possible new research program in the field of science and religion. At the center of the program lies an attempt to develop a new theology of nature drawing on the philosophy of C. S. Peirce. Our overall idea is that the fundamental structure of the world is exactly that required for the emergence of meaning and truth-bearing representation. We understand the emergence of a capacity to interpret an (...) environment to be important to the emergence of life, and we see the subsequent history of biological evolution as a story of increasing capacities for meaning-making and -seeking. Theologically, we understand God to be the ground of all such meaning-making and the ultimate goal of the universe's emerging capacity for interpreting signs. Here we summarize the articles in Part 1, which focused on scientific and philosophical aspects of the research program, and introduce Part 2, which turns to the theological outworking of the project. (shrink)

This book from the Center for Bioethics and Human Dignity provides a faith-based evaluation of recent technologies and trends in bioethics--including the current debate surrounding stem cell research. Fifteen noted scholars and medical practitioners discuss some of today's new and controversial work in biomedicine--xenotransplantation, artificial intelligence, cybernetics, and more--and evaluate from a Christian perspective both the science and the ethical questions it raises. Designed to orient general readers to the current state of biomedical research, Cutting-Edge Bioethics is must reading for (...) anyone wishing to confront and wrestle with the challenging moral issues posed by this ever-advancing field. (shrink)

Our goal is to use prototype analysis to distinguish the folk or culturally held understandings of love, romantic love, and sex and to specify, from the obtained data, the semantic relationship among these three associated concepts. By considering the semantic distinctions between these three concepts, we come to an unintended insight: if romantic love is a socio-cultural universal it does not appear to have the same evolutionary history as love or sex and this may account for its somewhat ambiguous status (...) in the scholarly literature on romantic love. We demonstrate that, in the United States, sex, in and of itself, is seldom conceived of as a relationship while love and romantic love are primarily viewed as relational. Our findings, though preliminary, strongly suggest that romantic love is a synthesis of two evolutionary drives: love and sex. (shrink)

Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR and SPINK1 variants were associated with pancreatitis risk. We now report two associations at genome-wide significance identified and replicated at PRSS1-PRSS2 and X-linked CLDN2 through a two-stage genome-wide study. The PRSS1 variant likely affects disease susceptibility by altering expression of the primary trypsinogen gene. The CLDN2 risk allele is (...) associated with atypical localization of claudin-2 in pancreatic acinar cells. The homozygous CLDN2 genotype confers the greatest risk, and its alleles interact with alcohol consumption to amplify risk. These results could partially explain the high frequency of alcohol-related pancreatitis in men. © 2012 Nature America, Inc. All rights reserved. (shrink)

This handbook presents a comprehensive introduction to the core areas of philosophy of education combined with an up-to-date selection of the central themes. It includes 95 newly commissioned articles that focus on and advance key arguments; each essay incorporates essential background material serving to clarify the history and logic of the relevant topic, examining the status quo of the discipline with respect to the topic, and discussing the possible futures of the field. The book provides a state-of-the-art overview of philosophy (...) of education, covering a range of topics: Voices from the present and the past deals with 36 major figures that philosophers of education rely on; Schools of thought addresses 14 stances including Eastern, Indigenous, and African philosophies of education as well as religiously inspired philosophies of education such as Jewish and Islamic; Revisiting enduring educational debates scrutinizes 25 issues heavily debated in the past and the present, for example care and justice, democracy, and the curriculum; New areas and developments addresses 17 emerging issues that have garnered considerable attention like neuroscience, videogames, and radicalization. The collection is relevant for lecturers teaching undergraduate and graduate courses in philosophy of education as well as for colleagues in teacher training. Moreover, it helps junior researchers in philosophy of education to situate the problems they are addressing within the wider field of philosophy of education and offers a valuable update for experienced scholars dealing with issues in the sub-discipline. Combined with different conceptions of the purpose of philosophy, it discusses various aspects, using diverse perspectives to do so. Contributing Editors: Section 1: Voices from the Present and the Past: Nuraan Davids Section 2: Schools of Thought: Christiane Thompson and Joris Vlieghe Section 3: Revisiting Enduring Debates: Ann Chinnery, Naomi Hodgson, and Viktor Johansson Section 4: New Areas and Developments: Kai Horsthemke, Dirk Willem Postma, and Claudia Ruitenberg. (shrink)

In February 54 b.c. Cicero concludes a missive to his brother with a passing and – for us – tantalizing remark: Lucreti poemata ut scribis ita sunt, multis luminibus ingeni, multae tamen artis. sed cum veneris. virum te putabo si Sallusti Empedoclea legeris; hominem non putabo. Quintus had, it seems, read De rerum natura, or at least parts thereof, just before he left Rome for an undisclosed location nearby, and he shared his enthusiasm with his brother per codicillos. Meanwhile, he (...) was corresponding with Julius Caesar, whose staff in Gaul he was about to join. When, a few months later, he was stationed with Caesar, he was involved in another literary affair, this time concerning his brother who wrote to him, inquiring about his autobiographical De temporibus suis: quo modo nam, mi frater, de nostris versibus Caesar? nam primum librum se legisse scripsit ad me ante, et prima sic ut neget se ne Graeca quidem meliora legisse; reliqua ad quendam locum ῥᾳθυμότερα. dic mihi verum: num aut res eum aut χαρακτὴρ non delectat? (shrink)

The party registration of tenure‐track faculty at 11 California universities, ranging from small, private, religiously affiliated institutions to large, public, elite schools, shows that the “one‐party campus” conjecture does not extend to all institutions or all departments. At one end of the scale, U.C. Berkeley has an adjusted Democrat:Republican ratio of almost 9:1, while Pepperdine University has a ratio of nearly 1:1. Academic field also makes a tremendous difference, with the humanities averaging a 10:1 D:R ratio and business schools averaging (...) 1.3:1, and with departments ranging from sociology (44:1) to management (1.5:1). Across all departments and institutions, the D:R ratio is 5:1, while in the “soft” liberal‐arts fields, the ratio is higher than 8:1. These findings are generally in line with comparable previous studies. (shrink)

In 2012, a U.S. Institute of Medicine report called for a different approach to health care: “Left unchanged, health care will continue to underperform; cause unnecessary harm; and strain national, state, and family budgets.” The answer, they suggested, would be a “continuously learning” health system. Ethicists and researchers urged the creation of “learning health organizations” that would integrate knowledge from patient‐care data to continuously improve the quality of care. Our experience with an ongoing research study on atrial fibrillation—a trial known (...) as IMPACT‐AFib—gave us some insight into one of the challenges that will have to be dealt with in creating these organizations. Although the proposed educational intervention study placed no restrictions on what providers and health plans could do, the oversight team argued that the ethical principle of beneficence did not allow the researchers to be “bystanders” in relation to a control group receiving suboptimal care. In response, the researchers designed a “workaround” that allowed the project to go forward. We believe the experience suggests that what we call “bystander ethics” will create challenges for the kinds of quality improvement research that LHOs are designed to do. (shrink)

Formalised knowledge systems, including universities and research institutes, are important for contemporary societies. They are, however, also arguably failing humanity when their impact is measured against the level of progress being made in stimulating the societal changes needed to address challenges like climate change. In this research we used a novel futures-oriented and participatory approach that asked what future envisioned knowledge systems might need to look like and how we might get there. Findings suggest that envisioned future systems will need (...) to be much more collaborative, open, diverse, egalitarian, and able to work with values and systemic issues. They will also need to go beyond producing knowledge about our world to generating wisdom about how to act within it. To get to envisioned systems we will need to rapidly scale methodological innovations, connect innovators, and creatively accelerate learning about working with intractable challenges. We will also need to create new funding schemes, a global knowledge commons, and challenge deeply held assumptions. To genuinely be a creative force in supporting longevity of human and non-human life on our planet, the shift in knowledge systems will probably need to be at the scale of the enlightenment and speed of the scientific and technological revolution accompanying the second World War. This will require bold and strategic action from governments, scientists, civic society and sustained transformational intent. (shrink)

In 2012, a U.S. Institute of Medicine report called for a different approach to health care: “Left unchanged, health care will continue to underperform; cause unnecessary harm; and strain national, state, and family budgets.” The answer, they suggested, would be a “continuously learning” health system. Ethicists and researchers urged the creation of “learning health organizations” that would integrate knowledge from patient‐care data to continuously improve the quality of care. Our experience with an ongoing research study on atrial fibrillation—a trial known (...) as IMPACT‐AFib—gave us some insight into one of the challenges that will have to be dealt with in creating these organizations. Although the proposed educational intervention study placed no restrictions on what providers and health plans could do, the oversight team argued that the ethical principle of beneficence did not allow the researchers to be “bystanders” in relation to a control group receiving suboptimal care. In response, the researchers designed a “workaround” that allowed the project to go forward. We believe the experience suggests that what we call “bystander ethics” will create challenges for the kinds of quality improvement research that LHOs are designed to do. (shrink)

This book is a collection of secondary essays on America's most important philosophic thinkers—statesmen, judges, writers, educators, and activists—from the colonial period to the present. Each essay is a comprehensive introduction to the thought of a noted American on the fundamental meaning of the American regime.

In The Realm of Reason (2004), Christopher Peacocke develops a “generalized rationalism” concerning, among other things, what it is for someone to be “entitled”, or justified, in forming a given belief. In the course of his discussion, Peacocke offers two arguments to the best explanation that aim to undermine scepticism and establish a justification for our belief in the reliability of sense perception, respectively. If sound, these ambitious arguments would answer some of the oldest and most vexing epistemological problems. (...) In this paper I will evaluate these arguments, concluding that they are inconclusive at best. Despite offering some interestingly original arguments, Peacocke gives us no reason to think that scepticism is false, and that perception is generally reliable. (shrink)

Although it has long been known that time is a cue to causation, recent work with adults has demonstrated that causality can also influence the experience of time. In causal reordering (Bechlivanidis & Lagnado, 2013, 2016) adults tend to report the causally consistent order of events, rather than the correct temporal order. However, the effect has yet to be demonstrated in children. Across four pre-registered experiments, 4- to 10-year-old children (N=813) and adults (N=178) watched a 3-object Michotte-style ‘pseudocollision’. While in (...) the canonical version of the clip object A collided with B, which then collided with object C (order: ABC), the pseudocollision involved the same spatial array of objects but featured object C moving before object B (order: ACB), with no collision between B and C. Participants were asked to judge the temporal order of events and whether object B collided with C. Across all age groups, participants were significantly more likely to judge that B collided with C in the 3-object pseudocollision than in a 2-object control clip (where clear causal direction was lacking), despite the spatiotemporal relations between B and C being identical in the two clips (Experiments 1—3). Collision judgements and temporal order judgements were not entirely consistent, with some participants—particularly in the younger age range—basing their temporal order judgements on spatial rather than temporal information (Experiment 4). We conclude that in both children and adults, rather than causal impressions being determined only by the basic spatial-temporal properties of object movement, schemata are used in a top-down manner when interpreting perceptual displays. (shrink)

The concentration of low‐density lipoprotein (LDL) cholesterol (C) in plasma is a key determinant of cardiovascular disease risk and human genetic studies have long endeavoured to elucidate the pathways that regulate LDL metabolism. Massive genome‐wide association studies (GWASs) of common genetic variation associated with LDL‐C in the population have implicated SORT1 in LDL metabolism. Using experimental paradigms and standards appropriate for understanding the mechanisms by which common variants alter phenotypic expression, three recent publications have presented divergent and even contradictory findings. (...) Interestingly, although these reports each linked SORT1 to LDL metabolism, they did not agree on a mechanism to explain the association. Here, we review recent mechanistic studies of SORT1 – the first gene identified by GWAS as a determinant of plasma LDL‐C to be evaluated mechanistically. (shrink)

Molecular tumour boards (MTBs) offer recommendations for potentially effective, but potentially burdensome, molecularly targeted treatments to a patient's treating physician. In this paper, we discuss the question of who is responsible for ensuring that there is an adequate evidence base for any treatments recommended to a patient. We argue that, given that treating oncologists cannot usually offer a robust evaluation of the evidence underlying an MTB's recommendation, members of the MTB are responsible for ensuring that the evidence level is adequate. (...) We explore two models for how to share responsibility between MTB members. According to the first model, each MTB member, as well as the treating physician, should be held maximally and equally responsible for the recommendations. We argue that this insufficiently accounts for differences in roles and expertise of MTB members. We propose instead that responsibility is delegated via relationships of trust. We argue if these relationships of trust are to be instances of reasonable trust, (a) MTBs should offer a clinical representative to whom a treating physician may delegate the responsibility of ensuring there is sufficient evidence for treatment recommendations, (b) the relationships of trust between the representative and the other MTB members should be clearly defined, and (c) MTB members should be carefully selected. Treating oncologists retain a responsibility to consider general limitations of the evidence for targeted treatments in assessing whether the treatment recommendation offered by an MTB's representative is adequate for a given clinical situation. (shrink)

Human moral judgement may have evolved to maximize the individual's welfare given parochial culturally constructed moral systems. If so, then moral condemnation should be more severe when transgressions are recent and local, and should be sensitive to the pronouncements of authority figures (who are often arbiters of moral norms), as the fitness pay-offs of moral disapproval will primarily derive from the ramifications of condemning actions that occur within the immediate social arena. Correspondingly, moral transgressions should be viewed as less objectionable (...) if they occur in other places or times, or if local authorities deem them acceptable. These predictions contrast markedly with those derived from prevailing non-evolutionary perspectives on moral judgement. Both classes of theories predict purportedly species-typical patterns, yet to our knowledge, no study to date has investigated moral judgement across a diverse set of societies, including a range of small-scale communities that differ substantially from large highly urbanized nations. We tested these predictions in five small-scale societies and two large-scale societies, finding substantial evidence of moral parochialism and contextual contingency in adults' moral judgements. Results reveal an overarching pattern in which moral condemnation reflects a concern with immediate local considerations, a pattern consistent with a variety of evolutionary accounts of moral judgement. (shrink)